Plenary & Parallel Session Listing

Wednesday, June 26   7:00 PM–10:00 PM
Royce Hall

Plenary Session 1

Chair: Abby Dernburg, University of CA, Berkeley, USA

1- 7:10
Feedback and Self-Organization in Meiosis. Anne Villeneuve, Stanford University.

2- 7:40
WormBase - still growing upwards and outwards. Kevin Howe, The WormBase Consortium.

3- 7:45
Tactile Toy, Teaching Tool, or Transformative Technology? WormGUIDES EmbryoAtlas 1.0. William A. Mohler, Zhirong Bao, Daniel Colon Ramos, Hari Shroff, Jim Schaff, Ion Moraru, wormguides.org.

4- 7:50
WormAtlas Update. L. A. Herndon, Z. F. Altun, C. A. Wolkow, K. Fisher, C. Crocker, D. H. Hall.

5- 7:55
WormBook News. Jane E. Mendel, Qinghua Wang, Todd Harris, Paul Sternberg, Oliver Hobert, Martin Chalfie.

6- 8:00
Caenorhabditis Genetics Center. Aric Daul, Theresa Stiernagle, Julie Knott, Brittany Werre, Ann E. Rougvie.

7- 8:05
The viral 2A peptide technology to express multiple functional proteins from a single ORF in Caenorhabditis elegans. Arnaud Ahier, Sophie Jarriault.

8- 8:10
A genome-scale resource for in vivo tag-based protein function exploration in C. elegans.. Mihail S. Sarov, John I. Murray, Susanne Ernst, Andrei Pozniakovski, Elisabeth Loester, Stephan Janosch, Wadim Kapulkin, Siegfried Schloissnig, Anthony A. Hyman, The ModENCODE C. elegans TF binding sites group.

9- 8:15
The Million Mutation Project and Beyond. Owen Thompson, Mark Edgley, Pnina Strasbourger, Stephane Flibotte, Brent Ewing, Ryan Adair, Vinci Au, Iasha Chaudhry, Lisa Fernando, Harald Hutter, Joanne Lau, Angela Miller, Greta Raymant, Bin Shen, Jay Shendure, Jon Taylor, Emily Turner, LaDeana Hillier, Donald G. Moerman, Robert H. Waterston.

8:27 - Break

10- 9:00
Advances in Targeted Genome Editing Across Species: Heritable Designer “Knock-In” and “Knock-Out” Modifications. Te-Wen Lo, Catherine Pickle, Mark Gurling, Caitlin Schartner, Erika Anderson, Ed Ralston, Barbara J. Meyer.

11- 9:12
Heritable genome editing in C. elegans via CRISPR-Cas systems. Ari E. Friedland, Yonatan B. Tzur, Kevin M. Esvelt, Monica P. Colaiacovo, George M. Church, John A. Calarco.

12- 9:24
CRE-LoxP mediated gene inactivation to study the coordination between proliferation and differentiation. Suzan Ruijtenberg, Sander van den Heuvel.

13- 9:36
Magnetotaxis in C. elegans. Andrés G. Vidal-Gadea, Kristi A. Ward, Jonathan T. Pierce-Shimomura.

14- 9:48
FLP-13 neuropeptides released from the ALA neuron signal through FRPR-4 to regulate behavioral quiescence. Matthew Nelson, Tom Janssen, Liliane Schoofs, David Raizen.

Thursday, June 27   9:00 AM–12:00 NOON
Ackerman Grand Ballroom

Physiology I: Aging and Stress I

Chairs: Veena Prahlad, University of Iowa, USA and Jeremy Van Raamsdonk, Van Andel Research Institute, USA

15- 9:00
Counterbalance between BAG and URX neurons via guanylate cyclases controls lifespan homeostasis in C. elegans. T. Liu, D. Cai.

16- 9:12
PQM-1: the missing “DAE Factor” and key regulator of DAF-2-mediated development, longevity, and homeostasis. Ronald G. Tepper, Jasmine Ashraf, Rachel Kaletsky, Gunnar Kleemann, Coleen T. Murphy, Harmen J. Bussemaker.

17- 9:24
Analysis of mutation accumulation by large scale C. elegans whole genome mutation profiling. B. Meier, S. Cook, J. Weiss, A. Bailly, P. Campbell, Anton Gartner.

18- 9:36
TORC2 regulates SGK-1 in two opposing longevity pathways. M. Mizunuma, E. Neumann-Haefelin, N. Moroz, K. Blackwell.

19- 9:48
A CREB-Dependent Neuropeptide Signal from the Thermosensory AFD Neuron Regulates C. elegans Life Span at Warm Temperatures. Yen-Chih Chen, Wei-Chin Tseng, Chun-Liang Pan.

20- 10:00
FGT-1 is the sole glucose transporter in C. elegans and is central to aging pathways. Ying Feng, B. Williams, F. Koumanov, A. J. Wolstenholme, G. D. Holman.

10:12 - Break

21- 10:36
Sensory neuronal regulation of lifespan through modulating insulin-like peptides in C. elegans. Murat Artan, Dae-Eun Jeong, Dongyeop Lee, Young-Il Kim, Joy Alcedo, Seung-Jae Lee.

22- 10:48
HLH-30/TFEB is a conserved regulator of autophagy and modulates longevity in C. elegans. Louis R. Lapierre, C. Daniel De Magalhaes Filho, Philip R. McQuary, Chu-Chiao Chu, Orane Visvikis, Jessica T. Chang, Sara Gelino, Binnan Ong, Andrew Davis, Javier E. Irazoqui, Andrew Dillin, Malene Hansen.

23- 11:00
Regulation of SKN-1/Nrf by the germline longevity pathway. Michael J. Steinbaugh, Sri Devi Narasimhan, Stacey Robida-Stubbs, Prashant Raghavan, Theresa Operana, T. Keith Blackwell.

24- 11:12
Importance of Growth, Stress Defense, and NAD+-related Pathways for Dietary Restriction Longevity. Natalie Moroz, Juan J. Carmona, Edward Anderson, Anne Hart, David A. Sinclair, T. Keith Blackwell.

25- 11:24
Nonsense-mediated decay as a novel modulator of toxic CUG repeats in C. elegans. Susana M. Garcia, Yuval Tabach, Guinevere Lourenço.

26- 11:36
A high throughput chemical screen identifies a novel activator of dietary restriction. Mark S. Lucanic, Ravi Shah, Ivan Yu, Bob Hughes, Gordon Lithgow.

27- 11:48
Mating-induced somatic collapse reveals a novel soma-germline interaction. Cheng Shi, Coleen Murphy.

Thursday, June 27   9:00 AM–12:00 NOON
Bradley International Ballroom

Neurobiology I: Behavior

Chairs: Jagan Srinivasan, Worcester Polytechnic Institute, USA and Alexander Gottschalk, Goethe University, Germany

28- 9:00
Neuromodulation of C. elegans mechanosensation. Xiaoyin Chen, Martin Chalfie.

29- 9:12
Humidity sensation requires a conserved DEG/ENaC complex in multi-dendritic FLP neurons. Josh Russell, Jonathan Pierce-Shimomura.

30- 9:24
CEPsh glia modulate a sleep-related neuronal circuit in C. elegans. Menachem Katz, Francis Corson, Shachar Iwanir, Elena Dragomir, David Biron, Shai Shaham.

31- 9:36
A neuronal mechanism for navigation along a repulsive odor gradient. Akiko Yamazoe, Yuki Tanimoto, Kosuke Fujita, Yuya Kawazoe, Yosuke Miyanishi, Shuhei Yamazaki, Xianfeng Fei, Karl Emanuel Busch, Keiko Gengyo-Ando, Junichi Nakai, Yuichi Iino, Yuishi Iwasaki, Koichi Hashimoto, Kotaro Kimura.

32- 9:48
Multiple cholinergic pathways for excitation of the Caenorhabditis elegans pharynx. Nicholas Trojanowski, Olivia Padovan-Merhar, David Raizen, Christopher Fang-Yen.

33- 10:00
Pathogen-induced changes of neuronal TGF-β signaling promote avoidance behavior and survival. Joshua D. Meisel, Dennis H. Kim.

10:12 - Break

34- 10:36
Nematophagous fungi eavesdrop on nematode pheromones, and lure their prey with attractive volatile organic compounds. Yen-Ping Hsueh, Erich Schwarz, Weihua Zeng, Zhaoying Xian, Parag Mahanti, Matthew Gronquist, Frank Schroeder, Ali Mortazavi, Paul Sternberg.

35- 10:48
Sensory neurons override recurrent motor programs to induce ejaculation during mating. Brigitte L. LeBoeuf, L. Rene Garcia.

36- 11:00
eol-1, the homolog of mammalian Dom3z, is a novel genetic regulator of C. elegans olfactory learning. Yu Shen, Jiangwen Zhang, John Calarco, Yun Zhang.

37- 11:12
Membrane phospholipids that contain arachidonic acid regulate touch receptor neuron mechanics and touch sensation. V. Vásquez, M. Krieg, D. Lockhead, M. B. Goodman.

38- 11:24
Serotonin and PDF are opposing neuromodulators that control a bistable foraging behavior in C. elegans. Steven W. Flavell, Navin Pokala, Evan Z. Macosko, Dirk A. Albrecht, Johannes Larsch, Cornelia I. Bargmann.

39- 11:36
Adenosine signaling in C. elegans: does skin rule the brain? Hsiao-Fen Han, Michael Ailion, Mary Beckerle, Erik Jorgensen.

40- 11:48
Chemosensing a predator: Pristionchus pacificus and C. elegans. Kevin Curran, Ada Tong, Matthew Joens, James Fitzpatrick, Jagan Srinivasan, Sreekanth Chalasani.

Thursday, June 27   9:00 AM–12:00 NOON
Grand Horizon Ballroom

Development and Evolution I: Germline Development, Meisosis and Sex Determination

Chairs: Sarit Smolikove, University of Iowa, USA and Swathi Arur, University of Texas MD Anderson Cancer Center, USA

41- 9:00
ZTF-8 interacts with the 9-1-1 complex and is required for DNA damage response and double-strand break repair in the C. elegans germline. Hyun-Min Kim, Monica Colaiacovo.

42- 9:12
Interplay between structure-specific endonucleases for crossover control during meiosis. Takamune T. Saito, Doris Y. Lui, Hyun-Min Kim, Katherine Meyer, Monica P. Colaiácovo.

43- 9:24
Sperm-derived TRP-3 channel specifies the onset of the fertilization Ca²⁺ wave in the oocyte of C. elegans. J. Takayama, S. Onami.

44- 9:36
Gap junctions between soma and germline regulate germ cell proliferation, meiotic maturation, and early embryogenesis. Todd Starich, David Hall, David Greenstein.

45- 9:48
Evidence for a meiotic crossover surveillance system. T. Machovina, O. McGovern, A. Woglar, D. Paouneskou, V. Jantsch, J. Yanowitz.

46- 10:00
Interchangeable α-kleisin subunits specify meiotic cohesin function in C. elegans. Aaron F. Severson, Barbara J. Meyer.

10:12 - Break

47- 10:36
A spatial and temporal transcriptomic survey of gene expression in the C. elegans embryo reveals organizing principles in cell fate specification. Tamar Hashimshony, Martin Feder, David Silver, Avital Polsky, Michal Levin, Itai Yanai.

48- 10:48
LIN-41 and OMA-1/2 spatially control M-phase entry during oogenesis. Caroline Spike, Donna Coetzee, David Greenstein.

49- 11:00
Molecular Antagonism between X-Chromosome and Autosome Signals Determines Sex. Behnom Farboud, Paola Nix, Margaret Jow, John Gladden, Barbara Meyer.

50- 11:12
The role of an SLC6 family transporter in C. elegans sperm activation. Kristin Fenker, Angela Hansen, Conrad Chong, Molly Jud, Gillian Stanfield.

51- 11:24
Regulation of lineage-specific transcription factors by Wnt signaling in C. elegans embryogenesis: more than one way to regulate expression. Amanda L. Zacharias, Travis Walton, Joshua T. Burdick, Elicia Preston, John I. Murray.

52- 11:36
Two molecularly distinct 3’end-directed translational control mechanisms establish two identical protein gradients in germ cells. Ryuji Minasaki, Nick Jourjine, Anfisa Solovyeva, Beate Kuechler, Christian R. Eckmann.

53- 11:48
The hazards of love: Sterilization and lethality in interspecies crosses. JJ Ting, GC Woodruff, T. Maugel, N. Kanzaki, RJ Sommer, AD Cutter, ES Haag.

Thursday, June 27   9:00 AM–12:00 NOON
Northwest Auditorium

Cell Biology I: Morphogenesis, Migration, Cytoskeleton

Chairs: Shuichi Onami, RIKEN Quantitative Biology Center, Japan and Bryan Phillips, University of Iowa, USA

54- 9:00
A pathway for unicellular tube extension depending on the lymphatic vessel determinant Prox1 and on osmoregulation. Irina Kolotueva, Vincent Hyenne, Yannick Schwab, David Rodrigues, Michel Labouesse.

55- 9:12
NHR-67 mediates cell cycle arrest and promotes the differentiation of the invasive phenotype. David Q. Matus, Laura C. Kelley, Michalis Barkoulas, Adam J. Schindler, Qiuyi Chi, Marie-Anne Félix, David R. Sherwood.

56- 9:24
UNC-84 spans the nuclear envelope and connects the nucleoskeleton to KASH proteins at the outer nuclear membrane. Natalie Cain, Courtney Bone, Erin Tapley, Ben Lorton, Kent McDonald, Daniel Starr.

57- 9:36
Endocytosis controls EFF-1 mediated cell fusion. K. Smurova, B. Podbilewicz.

58- 9:48
A new model system for studying cell shape change: identifying the molecular mechanisms necessary for C. elegans uterine seam cell development. Srimoyee Ghosh, Paul Sternberg.

59- 10:00
Dynamic interaction between hemidesmosomes and actin cytoskeleton regulated by RNA alternative splicing in elongating C.elegans epidermis. H. Zhang, R. Fu, H. Zahreddine, M. Labouesse.

10:12 - Break

60- 10:36
Excretory canal development requires conserved kinases and exc-6/INF2, a formin implicated in kidney disease. Daniel Shaye, Iva Greenwald.

61- 10:48
A Rho-specific GAP functions in response to axonal guidance signals to regulate embryonic morphogenesis. Andre Wallace, Sanese Brown, Martha Soto.

62- 11:00
ZEN-4/MKLP1 and the establishment of epithelial polarity in the C. elegans foregut. Stephen E. Von Stetina, Susan E. Mango.

63- 11:12
A Pre-Stressed UNC-70 β-Spectrin Network Governs the Sense of Touch. Michael Krieg, Alexander R. Dunn, Miriam B. Goodman.

64- 11:24
Understanding the Role of MMPs In Basement Membrane Breaching In Vivo. Laura C. Kelley, David Q. Matus, Qiuyi Chi, David R. Sherwood.

65- 11:36
The PAF1 complex is essential for epidermal morphogenesis in C. elegans embryos. Yukihiko Kubota, Yusuke Takabayashi, Kenji Tsuyama, Nami Haruta, Rika Maruyama, Asako Sugimoto.

66- 11:48
Nuclear membrane proteins act in transport of the Netrin receptor, UNC-5 in cell migration in C. elegans. Hon-Song Kim, Kiyoji Nishiwaki.

Thursday, June 27   3:00 PM–6:00 PM
Royce Hall

Plenary Session 2

Chair: Bruce Bowerman, University of Oregon, USA

67- 3:00
No title at time of print. Tony Hyman, Max Planck Institute.

68- 3:30
In vivo forced reprogramming and remodeling of differentiated somatic cells and organs by brief expression of a single transcription factor. Misty R. Riddle, Ken K. C. Q. Nguyen, David H. Hall, Joel H. Rothman.

69- 3:42
Evolution and genetic architecture of the first mitotic spindle in C. elegans. R. Farhadifar, C. Baer, E. Andersen, G. Fabig, T. Müller-Reichert, M. Delattre, D. Needleman.

70- 3:54
Meiotic chromosome structures constrain and respond to designation of crossover sites. Diana E. Libuda, Satoru Uzawa, Barbara J. Meyer, Anne M. Villeneuve.

71- 4:06
A sulfatase encodes a developmental switch for a feeding-structure dimorphism and controls micro- and macroevolutionary patterns in Pristionchus. Erik J. Ragsdale, Manuela R. Müller, Ralf J. Sommer.

72- 4:18
Axons degenerate in the absence of mitochondria. Randi Rawson, Lung Yam, Robby Weimer, Eric Bend, Erika Hartwieg, H. Robert Horvitz, Scott Clark, Erik Jorgensen.

4:30 - Break

73- 5:00
MATH-33, a conserved DUB required for DAF-16/FOXO stabilization and function. Thomas Heimbucher, Zheng Liu, Carine Bossard, Andrea Carrano, Richard McCloskey, Christian G. Riedel, Bryan R. Fonslow, Christian Klammt, Celine Riera, Kenneth Kemphues, Björn F. Lillemeier, John R. Yates III, Clodagh O'Shea, Tony Hunter, Andrew Dillin.

74- 5:12
DAF-16(FOXO) employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Christian G. Riedel, Robert H. Dowen, Guinevere F. Lourenco, Natalia V. Kirienko, Thomas Heimbucher, Jason A. West, Sarah K. Bowman, Robert E. Kingston, Andrew Dillin, John M. Asara, Gary Ruvkun.

75- 5:24
Life in the hot seat: Comparing aging and stress resistance. Nicholas Stroustrup, Zachary Nash, Javier Apfeld, Walter Fontana.

76- 5:36
The functional and regulatory organization of the C. elegans insulin-like peptide network. D. A. Fernandes de Abreu, A. Caballero, P. Fardel, N. Stroustrup, Z. Chen, K. Lee, W. D. Keyes, Z. M. Nash, I. F. López Moyado, F. Vaggi, A. Cornils, M. Regenass, A. Neagu, I. Ostojic, C. Liu, D. Sifoglu, W. Fontana, A. Csikasz-Nagy, C. Murphy, A. Antebi, E. Blanc⁺¹, J. Apfeld⁺⁴, Y. Zhang⁺⁵, J. Alcedo^+2,8, Q. Ch'ng⁺¹ * Shared first author + Corresponding author.

77- 5:48
Succinylated octopamine ascarosides and a new pathway of biogenic amine metabolism in C. elegans. Alexander B. Artyukhin, Joshua J. Yim, Jagan Srinivasan, Yevgeniy Izrayelit, Neelanjan Bose, Stephan H. von Reuss, James M. Jordan, L. Ryan Baugh, Paul W. Sternberg, Leon Avery, Frank C. Schroeder.

Friday, June 28   9:00 AM–12:00 NOON
Ackerman Grand Ballroom

Physiology II: Aging and Stress II

Chairs: Elke Neumann-Haefelin, Freiburg University, Germany and Arjumand Ghazi, University of Pittsburgh School of Medicine, USA

78- 9:00
Discovering Conserved Mechanisms of Protection against Ischemia-reperfusion Injury Using a Novel C. elegans Behavioral Model. Dengke K. MA, Bob Horvitz.

79- 9:12
Apoptotic hyperfunction causes gonadal atrophy in aging C. elegans. Yila de la Guardia, Ann Gilliat, Josephine Hellberg, David Gems.

80- 9:24
Molecular Outsourcing: Reproductive Signals Deploy NHR-49/PPARα to Reorganize Lipid Homeostasis and Alter Lifespan. Ramesh Ratnappan, Jordan Ward, Francis RG Amrit, Hasreet Gill, Kyle Holden, Keith Yamamoto, Arjumand Ghazi.

81- 9:36
Serotonergic signaling modulates the heat shock response in C. elegans. Veena Prahlad, Richard Morimoto.

82- 9:48
The conserved SKN-1/Nrf2 stress response pathway regulates synaptic function in Caenorhabditis elegans. Trisha Staab, Trevor Griffen, Connor Corcoran, Oleg Evgrafov, James Knowles, Derek Sieburth.

83- 10:00
Worms That Exercise Age Better. Daniel Burke, Mary Anne Royal, Leo Gefter, Christina Chang, Monica Driscoll.

10:12 - Break

84- 10:36
Perturbations of Glycolytic Flux Differentially Impact Healthspan via the Insulin Signaling and Dietary Restriction Pathways. Brian Onken, Monica Driscoll.

85- 10:48
Regulation of C. elegans Reproductive Aging by a Novel Gene-Environment Signaling Mechanism. Jessica Sowa, Meng Wang.

86- 11:00
Molecular determinants of longevity in C. elegans and the relationship between lifespan, “health span”, and the rate of aging. Zachary Pincus, Frank Slack.

87- 11:12
The conserved PBAF nucleosome remodeling complex mediates the response to stress in C. elegans. Aleksandra Kuzmanov, Evguenia Karina, Natalia Kirienko, David Fay.

88- 11:24
The tune of Insulin/IGF-1 signaling pathway set by lincRNAs. Pengpeng Liu, Min Liu, Li Zhang, Zhenglin Yang, Kai Xiong, Wei Dong, Wenxia Zhang, Zuoyan Zhu, Qichang Fan, Dong Liu.

89- 11:36
Mitochondrial ROS promote longevity and innate immunity via a feedback loop involving HIF-1 and AMPK. Ara B. Hwang, Eun-A Ryu, Murat Artan, William Mair, Seung-Jae Lee.

90- 11:48
How to live without water: Molecular strategies of the dauer larva to survive extreme desiccation. Cihan Erkut, Sider Penkov, Sebastian Boland, Andrej Vasilj, Hassan Khesbak, Daniela Vorkel, Bianca Habermann, Jean-Marc Verbavatz, Karim Fahmy, Andrej Shevchenko, Teymuras V. Kurzchalia.

Friday, June 28   9:00 AM–12:00 NOON
Bradley International Ballroom

Gene Expression I: RNA Interference and Small RNAs

Chairs: John Murray, University of Pennsylvania, USA and Julie Claycomb, University of Toronto, Canada

91- 9:00
Heterochromatin organization through development: regulated anchorage by H3K9 methylation and a novel chromodomain protein. Susan M. Gasser, Benjamin Towbin, Adriana Gonzalez, Peter Zeller, Véronique Kalck.

92- 9:12
Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence. Yuval Tabach, Allison Billi, Gabriel Hayes, Martin Newman, Or Zuk, Harrison Gabel, Ravi Kamath, Brab Chapman, Susana Garcia, Mark Borowsky, John Kim, Gary Ruvkun.

93- 9:24
The CSR-1 22G-RNA pathway modulates histone H3 modifications associated with euchromatin. Christopher J. Wedeles, Julie M. Claycomb.

94- 9:36
Positive regulation of Pol II transcription by CSR-1 RNAi pathway in C. elegans. Germano Cecere, Ravi Sachidanandam, Sebastian Hoersh, Alla Grishok.

95- 9:48
Characterization of the AGO protein VSR-1 in small RNA-mediated gene silencing pathways in the worm. Monica Z. Wu, Julie M. Claycomb.

96- 10:00
Involvement of C. elegans let-7-Family developmental timing microRNAs in bacterial pathogen response. Zhiji Ren, Victor Ambros.

10:12 - Break

97- 10:36
In vivo quantitative analysis of the heterochronic pathway reveals extensive target specificity of individual let-7 miRNA family members. Matyas Ecsedi, Helge Grosshans.

98- 10:48
MUT-14 and SMUT-1 are redundantly required for germline RNAi and endogenous siRNA production. Carolyn M. Phillips, Taiowa A. Montgomery, Peter C. Breen, Gary Ruvkun.

99- 11:00
The essential CHORD protein CHP-1 functions in small RNA pathways in C. elegans. Wendy X. Cao, Julie M. Claycomb.

100- 11:12
Periodic A/T rich DNA structures promote germline expression. C. Frokjaer-Jensen, M. W. Davis, E. M. Jorgensen.

101- 11:24
The period protein homolog LIN-42 negatively regulates microRNA biogenesis in C. elegans. Priscilla M. Van Wynsberghe, Emily F. Finnegan, Thomas J. Stark, Evan P. Angelus, Kathryn Homan, Gene W. Yeo, Amy E. Pasquinelli.

102- 11:36
Arginine methylation is required for piRNA mediated gene silencing in Caenorhabditis elegans. Alexandra Sapetschnig, Peter Sarkies, Eric Miska.

103- 11:48
ALG-3/4 acts through the CSR-1 pathway to promote spermiogenic gene expression and to provide a paternally inherited memory of past gene expression. Colin Conine, James Moresco, John Yates, Craig Mello.

Friday, June 28   9:00 AM–12:00 NOON
Grand Horizon Ballroom

Development and Evolution II: Cell Death, Development and Evolution

Chairs: Sophie Jarriault, Strasbourg University, France and Andre Pires da Silva, University of Warwick, United Kingdom

104- 9:00
let-70, an E2 ubiquitin-conjugating enzyme, promotes linker cell death in C. elegans. Jennifer A. Zuckerman, Yun Lu, Shai Shaham.

105- 9:12
Translational Regulators GCN-1 and ABCF-3 Maternally Contribute to General Programmed Cell Death. Takashi Hirose, Bob Horvitz.

106- 9:24
The importance of multiple caspase downstream pathways to execution of cell death in C. elegans. Akihisa Nakagawa, Yu-Zen Chen, Ding Xue.

107- 9:36
A Redox Signaling Globin Regulates Germ Cell Apoptosis in Caenorhabditis elegans. S. De Henau, L. Tilleman, M. Pauwels, A. Pesce, M. Nardini, M. Bolognesi, K. De Wael, L. Moens, S. Dewilde, B. P. Braeckman.

108- 9:48
A non-canonical role for the Caenorhabditis elegans dosage compensation complex in growth and metabolic regulation downstream of TOR complex 2. Christopher M. Webster, Denzil Douglas, Alexander A. Soukas.

109- 10:00
WormGUIDES: an overview. Zhirong Bao, William Mohler, Javier Marquina, Hari Shroff, Daniel A. Colon-Ramos.

10:12 - Break

110- 10:36
Using natural variation to decipher the complex genetic causes of C. elegans drug sensitivities. Erik C. Andersen, Tyler Shimko.

111- 10:48
Evolution of sperm activation in Caenorhaditis hermaphrodites. Qing Wei, Ronald E. Ellis.

112- 11:00
Specificity of interaction between Caenorhabditis and their natural viruses. Gautier Bresard, Marie-Anne Felix.

113- 11:12
Influence of the Microbiome on C. elegans Growth in the Wild. Buck S. Samuel, Holli Rowedder, Christian Braendle, Marie-Anne Félix, Gary Ruvkun.

114- 11:24
Evolution of Caenorhabditis Dosage Compensation. Te-Wen Lo, Caitlin Schartner, Barbara J. Meyer.

115- 11:36
Sumoylated NHR-25/NR5A regulates cell fate during C. elegans vulval development. Jordan D. Ward, Nagagireesh Bojanala, Teresita Bernal, Kaveh Ashrafi, Masako Asahina, Keith Yamamoto.

116- 11:48
Vulva Precursor Cells dynamically regulate their sensitivity to the LIN-3/EGF morphogen gradient to control Notch ligand expression during vulva induction. Jeroen S. van Zon, Alexander van Oudenaarden.

Friday, June 28   9:00 AM–12:00 NOON
Northwest Auditorium

Neurobiology II: Neuronal Development

Chairs: Xiao Liu, Tsinghua University, China and Dan Chase, University of Massachusetts, Amherst, USA

117- 9:00
Synapse location during growth depends on glia location. Z. Shao, S. Watanabe, R. Christensen, E. Jorgensen, D. Colón-Ramos.

118- 9:12
Attenuation of insulin signaling contributes to FSN-1-mediated regulation of synapse development. Wesley L. Hung, Christine Hwang, ShangBang Gao, Edward H. Liao, Jyothsna Chitturi, Ying Wang, Hang Li, Christian Stigloher, Jean-Louis Bessereau, Mei Zhen.

119- 9:24
MicroRNA regulation of proteoglycan biosynthesis controls cell migration in C. elegans. Mikael Pedersen, Goda Snieckute, Konstantinos Kagias, Camilla Nehammer, Hinke Mulhaupt, John Couchman, Roger Pocock.

120- 9:36
Identification of a novel axon guidance regulator. Nanna Torpe, Roger Pocock.

121- 9:48
Reversible dendrite arborization in dauers is regulated by KPC-1/furin. Nathan Schroeder, Rebecca Androwski, Alina Rashid, Harksun Lee, Junho Lee, Maureen Barr.

122- 10:00
Axonal fusion in regenerating axons shares molecular components with the apoptotic cell recognition pathway. Brent Neumann, Sean Coakley, Hengwen Yang, Ding Xue, Massimo Hilliard.

10:12 - Break

123- 10:36
Inhibition of precocious DD motor neuron synapse formation by the single Ig domain protein, OIG-1. Kelly L. Howell, Oliver Hobert.

124- 10:48
GRDN-1/Girdin and SAX-7/L1CAM establish a glial guide for sensory dendrite extension. Ian G. McLachlan, Maxwell G. Heiman.

125- 11:00
Genes that function downstream of Notch define a novel mechanism for inhibiting axon regeneration. Rachid El Bejjani, Marc Hammarlund.

126- 11:12
The LAD-2/L1CAM functions in EFN-4/ephrin-mediated axon guidance. Binyun Dong, Melinda Moseley-Alldredge, Lihsia Chen.

127- 11:24
Brain-wide Ca²⁺-imaging of neural activity in Caenorhabditis elegans. T. Schroedel, R. Prevedel, K. Aumayr, A. Vaziri, M. Zimmer.

128- 11:36
A database of C. elegans behavioral phenotypes. Eviatar I. Yemini, Laura J. Grundy, Tadas Jucikas, Andre E. X. Brown, William R. Schafer.

Friday, June 28   1:30 PM–4:30 PM
Royce Hall

Plenary Session 3

Chair: Michael Hengartner, University of Zurich, Switzerland

129- 1:30
Cell-cell fusion, sculpting and mechanisms. Benjamin Podbilewicz, Technion - Israel Institute of Technology.

130- 2:00
The midbody ring, not the midbody microtubules, dictates abscission patterning in vivo. Rebecca A. Green, Jonathan Mayers, Lindsay Lewellyn, Arshad Desai, Anjon Audhya, Karen Oegema.

131- 2:12
In vivo visualization of chromosome synapsis in C. elegans. Ofer Rog, Abby F. Dernburg.

132- 2:24
The development of non-centrosomal MTOCs during epithelial polarization. Jessica L. Feldman, James R. Priess.

133- 2:36
C. elegans meets single-molecule detection technologies; The embryonic cell polarity system is driven by state transition of PAR-2 protein molecules. Yukinobu Arata, Tetsuya Kobayashi, Michio Hiroshima, Chan-gi Pack, Tatsuo Shibata, Yasushi Sako.

134- 2:48
Analyses of C. elegans enhancer and promoter architectures reveals CpG island-like sequences and promoter activity of HOT regions. R. Chen, T. Down, E. Zeiser, P. Stempor, Q. Chen, T. Egelhofer, L. Hillier, T. Jeffers, J. Ahringer.

3:00 - Break

135- 3:30
Neuropeptide Secreted from a Pacemaker Activates Neurons to Control a Rhythmic Behavior. Han Wang, Kelly Girskis, Tom Janssen, Jason P. Chan, Krishnakali Dasgupta, James A. Knowles, Liliane Schoofs, Derek Sieburth.

136- 3:42
Tasting Light: A C. elegans Pharyngeal Neuron Senses Hydrogen Peroxide Produced by Light. Nikhil Bhatla, Bob Horvitz.

137- 3:54
The connectome of the anterior nervous system of the C. elegans adult male. Travis A. Jarrell, Yi Wang, Adam E. Bloniarz, Steven J. Cook, Christopher A. Brittin, Kenneth Nguyen, Meng Xu, David H. Hall, Scott W. Emmons.

138- 4:06
The degenerin family ion channel UNC-8 promotes activity-dependent remodeling of GABAergic synapses in C. elegans. Tyne W. Miller, Sarah C. Petersen, Megan E. Gornet, Ying Wang, Han Lu, Cristina Matthewman, Shohei Mitani, Sayaka Hori, Laura Bianchi, Janet Richmond, David M. Miller.

139- 4:18
Epidermal Growth Factor signaling mediates heat-induced quiescence in C. elegans. Andrew Hill, Cheryl Van Buskirk.

Friday, June 28   5:00 PM–6:00 PM
Royce Hall

Plenary Session 4 - Keynote Address

Chair: Gary Ruvkun, Massachusetts General Hospital, USA

140- 5:00
Heterochronic Genes and Developmental Timing in C. elegans. Victor Ambros, Univ. of Massachusetts Medical School.

Saturday, June 29   9:00 AM–12:00 NOON
Ackerman Grand Ballroom

Gene Expression II: Gene Expression, Genomics and Epigenetics

Chairs: Amy Walker, University of Massachusetts, USA and Sam Gu, Rutgers University, USA

141- 9:00
Feedback Control of Gene Expression Variability in the Caenorhabditis elegans Wnt pathway. Ni Ji, Teije Middelkoop, Remco Mentink, Hendrik Korswagen, Alexander van Oudenaarden.

142- 9:12
Integral nuclear pore components associate with Pol III-transcribed genes and are required for Pol III transcript processing in C. elegans. Kohta Ikegami, Jason Lieb.

143- 9:24
The regulation of global histone acetylation during meiotic prophase in C.elegans. Jinmin Gao, Hyun-Min Kim, Andrew E. Elia, Stephen J. Elledge, Monica P. Colaiácovo.

144- 9:36
Tissue integrity and laminopathic phenotypes correlate with subnuclear heterochromatin positioning. A. Mattout, SM. Gasser.

145- 9:48
A Comprehensive Expression Map of Lysine Methyltransferases Reveals Germline-specific Function of set-17. Christoph G. Engert, Alexander van Oudenaarden, Bob Horvitz.

146- 10:00
MRG-1 acts as an epigenome interpreter of Lys36 methylation on histone H3. Teruaki Takasaki, Thea Egelhofer, Andreas Rechtsteiner, Hiroshi Sakamoto, Susan Strome.

10:12 - Break

147- 10:36
Control of DNA accessibility by histone H2A variants revealed using in vitro analysis of C. elegans nucleosomes. Ahmad N. Nabhan, Francisco Guerrero, Geeta Narlikar, Diana Chu.

148- 10:48
Epigenetic reprograming during germ line development. B. Hargitai, I. Kalchhauser, S. Gutnik, R. Ciosk.

149- 11:00
Spatial Control of Gene Expression in the C. elegans Intestine. Aidan Dineen, Jim McGhee.

150- 11:12
Defining regulatory pathway coupling cell division timing and cell fate differentiation in C. elegans by automated lineaging. Vincy Wing Sze Ho, Ming-Kin Wong, Xiaomeng An, Jiaofang Shao, Kan He, Dongying Xie, Jinyue Liao, Long Chen, Xiaotai Huang, Leanne Chan, King Chow, Hong Yan, Zhongying Zhao.

151- 11:24
Linking dosage compensation complex assembly to X chromosome gene regulation. Bayly Wheeler, Christian Frøkjær-Jensen, Erik Jorgensen, Barbara J. Meyer.

152- 11:36
Silencing of Germline-Expressed Genes by DNA Elimination in Somatic Cells and a Mechanism for Selective DNA Segregation. Richard E. Davis, Jianbin Wang, Makedonka Mitreva, Matthew Beriman, Alicia Thorne, Vincent Magrini, Stella Kratzer, Maggie Balas, Georgios Koutsovoulos, Sujai Kumar, Mark Blaxter.

153- 11:48
Exploring C. elegans heterochromatin through the HP1 homolog HPL-2. Jacob M. Garrigues, Susan Strome.

Saturday, June 29   9:00 AM–12:00 NOON
Northwest Auditorium

Cell Biology II: Cell Division, Cell Polarity and Fate

Chairs: Mike Boxem, Utrecht University, The Netherlands and Huimin Zhang, Suzhou University, China

154- 9:00
Aurora A is essential for the organization of the female meiotic spindle in late anaphase. Eisuke Sumiyoshi, Yuma Fukata, Asako Sugimoto.

155- 9:12
Formation of the nuclear envelope as a distinct subdomain of the endoplasmic reticulum requires spatial regulation of Lipin activation. Shirin Bahmanyar, Ronald Biggs, Jon Audhya, Arshad Desai, Jack Dixon, Thomas Mullert-Reichert, Karen Oegema.

156- 9:24
Homolog pairing and feedback control during meiosis are mediated through CHK-2 phosphorylation of pairing center proteins. Y. Kim, A. F. Dernburg.

157- 9:36
Intestinal pathogens hijack the host apical recycling pathway for fecal-oral transmission. Suzy Szumowski, Emily Troemel.

158- 9:48
Essential function for the exocyst complex in seamless tube formation. Stephen Armenti, Emily Chan, Jeremy Nance.

159- 10:00
A context-specific role for Syndecan/SDN-1 in Wnt-dependent spindle orientation. Katsufumi Dejima, Sukryool Kang, Andrew Chisholm.

10:12 - Break

160- 10:36
Cell signalling and membrane trafficking - an unbreakable relationship. Zita Balklava, Navin Rathnakumar.

161- 10:48
ttm-1 encodes CDF transporters that excrete zinc from intestinal cells of C. elegans and act in a parallel negative feedback circuit that promotes homeostasis. Hyun Cheol Roh, Sara Collier, Krupa Deshmukh, James Guthrie, J. David Robertson, Kerry Kornfeld.

162- 11:00
The SYS-1/β-catenin regulatory machinery controls multiple functions of APR-1/APC during seam cell division. Austin T. Baldwin, Bryan T. Phillips.

163- 11:12
CEH-20/Pbx and UNC-62/Meis function upstream of rnt-1/Runx to regulate asymmetric divisions of the C. elegans stem-like seam cells. Samantha L. Hughes, Charles Brabin, Alison Woollard.

164- 11:24
Regulation of maternal Wnt mRNA translation in C. elegans embryos reveals mechanistic parallels between 3’ UTRs and transcription enhancers. Marieke Oldenbroek, Scott Robertson, Tugba Guven-Ozkan, Caroline Spike, David Greenstein, Rueyling Lin.

165- 11:36
Life at the edge of robustness: Partial guts suggest that endoderm specification is not all-or-none. Morris F. Maduro, Francisco Carranza, Farhad Ghamsari, Gurjot Walia, Gina Broitman-Maduro.

166- 11:48
Identification of SEL-10/Fbw7 substrates regulated in cell fate patterning events via a conserved phosphodegron motif. Claire de la Cova, Iva Greenwald.

Saturday, June 29   9:00 AM–12:00 NOON
Grand Horizon Ballroom

Physiology III: Pathogenesis, Dauer Larvae and Metabolism

Chairs: William Mair, Harvard School of Public Health, USA and Sean Curran, University of Southern California, USA

167- 9:00
A Genome-Wide RNAi Screen of Caenorhabditis elegans Identifies Translational Machinery Genes Involved in Fat Regulation. Elizabeth Pino, Christopher Carr, Alexander Soukas.

168- 9:12
Identification of a novel C. elegans protein that detects bacteria. Darym Alden, Jonathan Dworkin.

169- 9:24
Nuclear Receptor NHR-8 Regulates Cholesterol, Bile Acid and Fat Metabolism, and Modulates Reproduction and Lifespan. Daniel Magner, Joshua Wollam, Yidong Shen, Caroline Hoppe, Dongling Li, Christian Latza, Veerle Rottiers, Harald Hutter, Adam Antebi.

170- 9:36
The Tumor Suppressor Rb Critically Regulates Starvation-induced Stress Response in C. elegans. Mingxue Cui, Huanhu Zhu, Max Cohen, Cindy Teng, Min Han.

171- 9:48
A novel ascaroside controls the parasitic life cycle of the entomopathogenic nematode Heterorhabditis bacteriophora. Jaime H. Noguez, Joshawna K. Nunnery, Elizabeth S. Connor, Yue Zhou, Todd A. Ciche, Justin R. Ragains, Rebecca A. Butcher.

172- 10:00
A Conserved SREBP/Transketolase Regulatory Circuit Governing Lipid Homeostasis in Metazoans. V. Rottiers, P. Mulligan, A. K. Walker, J. L. Watts, A. C. Hart, A. M. Näär.

10:12 - Break

173- 10:36
C.elegans community behavior affects the dynamics of pathogen avoidance. Andrzej Nowojewski, Erel Levine.

174- 10:48
Triggering antifungal innate immunity. Olivier Zugasti, Barbara Squiban, Jerome Belougne, Leo Kurz, Neelanjan Bose, Frank Schroeder, Nathalie Pujol, Jonathan Ewbank.

175- 11:00
The mir-58 family of microRNAs regulates the tissue-specific expression of PMK-2 p38 MAPK that functions in host defense. Daniel J. Pagano, Elena R. Kingston, Dennis H. Kim.

176- 11:12
Role of Manganese Homeostasis in Aging and Disease: Implications for Parkinson's Disease. Suzanne Angeli, Kathryn Page, David Killilea, Gordon Lithgow, Julie Andersen.

177- 11:24
HIF-1, DAF-16, and ZIP-2 coordinate the C. elegans defense against P. aeruginosa pathogenesis. Natalia Kirienko, Daniel Kirienko, Jonah Larkins-Ford, Gary Ruvkun, Fred Ausubel.

178- 11:36
A new role of DCR-1/DICER in C. elegans innate immunity against the highly virulent bacterium Bacillus thuringiensis DB27. Igor Iatsenko, Amit Sinha, Christian Rödelsperger, Ralf J. Sommer.

179- 11:48
A candidate host receptor exploited by microsporidia for intestinal infection in C. elegans. Robert J. Luallen, Malina Bakowski, Emily Troemel.

Saturday, June 29   9:00 AM–12:00 NOON
De Neve Plaza Room

Neurobiology III: Synaptic Function

Chairs: Manuel Zimmer, IMP-Research of Molecular Pathology, Austria and Elissa Hallem, Univ. of California, Los Angeles, USA

180- 9:00
The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons. Zhiping Wang, Yanli Hou, Xing Guo, Monique van der Voet, Jack Dixon, Mike Boxem, Yishi Jin.

181- 9:12
Feeding state, NPR-1 and circuit dynamics regulate chemoreceptor expression. Matt Gruner, Rebecca Hintz, Samuel Chung, Chris Gabel, Alexander van der Linden.

182- 9:24
Sensory responses to graded stimuli: a role in bidirectional chemotaxis? Michael Hendricks, Luo Linjiao, Aravi Samuel, Yun Zhang.

183- 9:36
Neuropeptide signaling remodels chemosensory circuit composition. Sarah Leinwand, Sreekanth Chalasani.

184- 9:48
Thermal memory and behavioral regulation revealed by calcium imaging of the cultured neurons and neural circuits. Kyogo Kobayashi, Ikue Mori.

185- 10:00
Functional memory loss: Msi-1 is an inhibitor of memory. Nils Hadziselimovic, Fabian Peter, Petra Hieber, Vanja Vukojevic, Philippe Demougin, Andreas Papassotiropoulos, Attila Stetak.

10:12 - Break

186- 10:36
Betaine acts on a ligand-gated ion channel in C. elegans. Aude S. Peden, Patrick Mac, You-Jun Fei, Cecilia Castro, Guoliang Jiang, Kenneth J. Murfitt, Eric A. Miska, Julian L. Griffin, Vadivel Ganapathy, Erik M. Jorgensen.

187- 10:48
Novel function of the polarity gene PAR-1 in control of activity at the NMJ. Clara L. Essmann, Emma Hiley, Zhitao Hu, Joshua Kaplan, Stephen Nurrish.

188- 11:00
Neuroligin organizes C. elegans GABAergic NMJs. Géraldine Maro, Shangbang Gao, Michael Liu, Mei Zhen, Kang Shen.

189- 11:12
Synaptic engineering: an ionic switch of behavior. Jennifer K. Pirri, Diego Rayes, Mark J. Alkema.

190- 11:24
Multiple independent calcium pools in a nociceptive neuron in C. elegans. Jeffrey Zahratka, Richard Komuniecki, Paul Williams, Bruce Bamber.

191- 11:36
Two Minds of a Worm: Comparison of the L4 and Adult Hermaphrodite Connectomes. S. Cook, C. Brittin, T. Jarrell, D. Hall, S. Emmons.

Sunday, June 30   9:00 AM–12:00 NOON
Royce Hall

Plenary Session 5

Chair: Ian Hope, University of Leeds, United Kingdom

192- 9:00
Gene Regulatory Networks. Marian Walhout, Univ. of Massachusetts Medical School.

193- 9:30
A Transdifferentiating Cell Requires Dynamic Histone Modifying Activities. Steven Zuryn, Arnaud Ahier, Marie Charlotte Morin, Sophie Jarriault.

194- 9:42
Holocentromeres are dispersed point centromeres localized at transcription factor hotspots. Florian A. Steiner, Steven Henikoff.

195- 9:54
A gene-activating pathway mediated by small RNAs (RNAa) protects self-transcripts from epigenetic silencing in C. elegans. Meetu Seth, Masaki Shirayama, Weifeng Gu, Takao Ishidate, Darryl Conte Jr., Craig C. Mello.

196- 10:06
X-Chromosome Restructuring Imposed by the Dosage Compensation Complex and Its Relationship to Nuclear Pores. Qian Bian, Emily Crane, Satoru Uzawa, Barbara J. Meyer.

197- 10:18
A Developmental Time Course of Transcription and Subsequent Computational Bayesian Unification Reveals Multiple Global Waves of Gene Regulation. Max E. Boeck, Chau Huynh, Lou Gevirtzman, Daniel Mace, LaDeana Hillier, Owen Thompson, Pnina Strasbourger, Guilin Wang, Valerie Reinke, Robert Waterston.

10:30 - Break

198- 11:00
Epigenetic control of terminal neuronal differentiation in Caenorhabditis elegans. Chaogu Zheng, Siavash Karimzadegan, Martin Chalfie.

199- 11:12
MNR-1/menorin, a novel skin-derived cue, controls arborization of sensory dendrites in C. elegans. Y. Salzberg, C. A. Diaz-Balzac, N. Ramirez, M. Attreed, E. Tecle, Z. Kaprielian, H. Buelow.

200- 11:24
Reduced Insulin/IGF1 signaling restores germ cell immortality to Caenorhabditis elegans prg-1 Piwi mutants. Matt A. Simon, Peter Sarkies, Kohta Ikegami, Leonard Goldstein, Aisa Sakaguchi, Eric Miska, Shawn Ahmed.

201- 11:36
A deletion polymorphism in the C. elegans RIG-I homolog disables antiviral siRNA formation and immunity. Jeremie Le Pen, Alyson Ashe, Peter Sarkies, Tony Bélicard, Amy Cording, Nicolas J. Lehrbach, Marie-Anne Félix, Eric A. Miska.

202- 11:48
Death by worm-star: a new way of killing C. elegans, with implications for ether lipid metabolism. Jonathan Hodgkin, Marie-Anne Félix, Laura C. Clark, Delia M. O'Rourke, Dave Stroud, Maria J. Gravato-Nobre.

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